Review supports Tinospora’s immune health benefits

While demand for products with vitamins C and D, zinc, elderberry, and echinacea surged in 2020, a lesser known ingredient – T.cordifolia – ​may also offer options to formulators as consumer interest in immune products shows no sign of slowing.

T. cordifolia​ is a deciduous climbing shrub native to India. The plant has a long history of use in Ayurveda to counter inflammation and “promote a balanced immune response”,​ explained reviewers from the University of Memphis, Huntington University of Health Sciences, and Methodist Germantown Hospital.

The reviewers stress that the vast majority of the data to date – both preclinical and clinical – is in response to bacterial infection, and “… caution should be exercised when extrapolating said activity to host viral responses since data to support such structure function claims are lacking”​.


“Extensive phytochemical characterization of aqueous and alcoholic extracts of different ​Tinospora species has identified over two hundred different phytochemicals from non-overlapping chemical classes with the most abundant being diterpenoids containing the clerodane-type skeleton,”​ they wrote in the Journal of Dietary Supplements

Other bioactive constituents linked to the immune benefits of extracts from the aerial parts of T.cordifolia ​(stem and/or leaf), include polysaccharides (for example, arabinogalactan polysaccharide G1-4A), alkaloids, cadinane sesquiterpenes, and phenylpropanoid glycosides.

“Representatives from each of the aforementioned chemical classes variously promote PMN phagocytosis and alter the balance of Th1 and Th2 cytokines,” ​wrote the reviewers in the. ​ 

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